DPI or Dots Per Inch is a measure of spatial dot density initially used in print. It’s the number of ink drops your printer can put in an inch . A smaller DPI yields a less-detailed image.

This concept is applied to computer screens under the name PPI for Pixels Per Inch. Same principle: It counts the number of pixels your screen can display per inch. The name DPI is also used in screens.

Windows computers have a default PPI of 96. Mac uses 72, although this value hasn’t been accurate since the 80’s.

Regular, non-retina desktops (mac included) will have a PPI of 72 minimum up to around 120 maximum. Designing with a PPI between 72 and 120 ensures your work is going to be roughly the same size ratio everywhere.

Here’s an applied example:
A Mac Cinema Display 27” has a PPI of 109, which means that it displays 109 pixels per inch of screen. The width with bevel is 25.7 inches (65cm). The width of the actual screen is approximately 23.5 inches so 23.5*109~2560, which makes the native screen resolution 2560x1440px.

Impact on your design

Let’s say you design a blue square of 109*109px on the screen we just talked about above. This square will have a physical size on the screen of 1*1 inch. But if your user has a screen with a PPI of 72, your blue square will appear physically bigger. Since the PPI is 72, the screen will need aproximately an inch and a half to display your blue square of 109px.

Screen resolution (and native resolution)

Screen resolution can have a huge impact on how the user perceives your design. Thankfully, since LCD monitors have replaced CRT ones, users now tend to have native screen resolutions that guarantee a good screen size/PPI ratio.

The resolution defines the number of pixels displayed on the screen (ex: 2560*1440px for the cinema display 27in.) 2560 is the width, 1440 is the height. Of course now that you know what PPI means, you understand that this can’t be an unit of measure of a physical size. You can have a 2560×1440 screen the size of your wall and another one the size of your head.

Today’s LCD monitors have a pre-defined default or native resolution that will handle the exact number of pixels that the screen is able to display. It was slightly different with old CRT monitors, but since those can be considered dead, let’s not enter into the details (and not reveal my only partial understanding of the good old TV).

Let’s take our 27” Cinema Display that can display 109 PPI at a native resolution of 2560*1440px. If you reduce the resolution, the elements will appear bigger. After all you’ll have 23.5 horizontal inches to fill with virtually less pixels.